MTOR and colorectal carcinoma: To further verify the inhibitory role of circEXOC6B in the positive feedback loop, we used IHC to evaluate the expression of HIF1A, RRAGB, and p-mTOR in the 22 CRC clinical samples used in Table S3, including 11 cases of low circEXOC6B expression and 11 cases of high circEXOC6B expression.