For instance, circGLIS3 promotes the proliferation of bladder cancer cells by adsorbing miR-1273f to upregulate cyclin D1 expression [26], circNDUFB2 inhibits cancer cell growth and metastasis and enhances anti-tumor immune responses by accelerating the ubiquitination of IGF2BP2 and recruiting immune cells into the tumor microenvironment in non-small cell lung cancer [27], the circRNAs CPM [28] and CRIM1 [29] promote chemoresistance in gastric cancer and nasopharyngeal carcinoma, respectively, and the circRNA Foxo3 inhibits chemoresistance in prostate cancer [30]. This evidence concerns the gene FOXO3 and Familial prostate cancer.