To further verify the inhibitory role of circEXOC6B in the positive feedback loop, we used IHC to evaluate the expression of HIF1A, RRAGB, and p-mTOR in the 22 CRC clinical samples used in Table S3, including 11 cases of low circEXOC6B expression and 11 cases of high circEXOC6B expression. This evidence concerns the gene HIF1A and colorectal carcinoma.