We found that NLRP3 inflammasome-associated genes were differentially expressed; IAV induced earlier and stronger airway inflammatory storms in DHBE cells and COPD rats by activating the NLRP3 inflammasome pathway, but MCC950 treatment could reverse the effects (e.g., MCC950 improved survival rate and suppressed inflammatory response in AECOPD rats). The gene discussed is NLRP3; the disease is chronic obstructive pulmonary disease.