IFNG and renal cell carcinoma: Contrary to the early stage RCC, the survival curves for the four models of immune-related signatures indicated more significant differences in the OS between the two groups from the advanced RCC (HLA-A and HLA-B: p value = 0.0015; IFN-gamma signature: p value = 9.787e-6; Expended immune gene signature: p value = 1.137e-11; Cytotoxic T cell lymphocyte signature: p value = 0.00011) as shown in Fig. 1.