Most of the differentially abundant taxa in tumor-adjacent tissue were negatively associated with EC 2.7.10.1, which regulated the epidermal growth factor receptor (EGFR), erb-b2 receptor tyrosine kinase 2 (ERBB2), erb-b2 receptor tyrosine kinase 4 (ERBB4), and fibroblast growth factor receptor 1 (FGFR1) signaling pathways. The gene discussed is ERBB2; the disease is neoplasm.