Based on the comparative pan-cancer analysis of these key CAF markers and a comprehensive literature search we identified COL1A1, COL5A1, ITGA4, EMILIN1, and TSPAN9 as the signature genes, which potentiated the poor prognostic impact of CAF infiltration specifically in stomach adenocarcinoma. The gene discussed is ITGA4; the disease is gastric adenocarcinoma.