Knockout of EMILIN11 or suppression of EMILIN-1 - integrin α4β1 interaction was associated with decreased expression of the tumor suppressor PTEN, and increased activity of PI3K/Akt and ERK1/2 pathways, leading to hyperproliferation of dermal fibroblasts and keratinocytes, increased skin carcinogenesis and lymph node metastasis [50, 53]. This evidence concerns the gene PTEN and metastatic malignant neoplasm in the lymph nodes.