COL1A1 and gastric adenocarcinoma: To understand whether the integrin α4β1 potentiates the poor prognostic impact of CAFs, we analyzed the Cox regression model for CAF infiltration that considers the expression of ITGA4, ITGB1, or both in addition to COL1A1 and COL5A1. The addition of ITGA4 to the model increased the hazard ratio and z-score in stomach adenocarcinoma (z = 2.963, HR = 12.247) (Table 4).