Hence the module analysis strengthened the connection of the six CAF markers: COL1A1, COL1A2, COL3A1, COL5A1, FN1 and, SPARC, with the 3 KEGG pathways: ECM-receptor interaction, focal adhesion and, PI3K-Akt signaling pathway in gastric cancer. The gene discussed is COL1A1; the disease is gastric cancer.