The opposite effect of this dual gene signature in adrenocortical carcinoma, kidney renal papillary cell carcinoma, and mesothelioma (Fig. 8e) led us to identify ITGA4, EMILIN11, and TSPAN9 as interactors that potentiate the poor prognostic effect of CAFs specifically in gastric cancer. Here, ITGA4 is linked to mesothelioma.