Notably, some possible mediators of obesity‐related SNS activation have been suggested, such as adipokines (like leptin, angiotensinogen, interleukin‐6, and tumor necrosis factor‐α), angiotensin II, hyperinsulinemia, impaired baroreceptor reflexes, and activated chemoreceptor reflexes.18 This evidence concerns the gene AGT and Hyperinsulinemia.