LEP and obesity due to melanocortin 4 receptor deficiency: Notably, some possible mediators of obesity‐related SNS activation have been suggested, such as adipokines (like leptin, angiotensinogen, interleukin‐6, and tumor necrosis factor‐α), angiotensin II, hyperinsulinemia, impaired baroreceptor reflexes, and activated chemoreceptor reflexes.18