It is therefore necessary for all nasopharyngeal carcinomas, both for diagnostic and therapeutic purposes, to test for the presence of EBV in the tumour tissue; such tests include IHC for latent membrane protein 1 (LMP-1) and in situ hybridization (ISH) for EBV-encoded small mRNAs (EBERs). The gene discussed is PDLIM7; the disease is neoplasm.