We also identified heterozygous P/LP variants in genes predisposing to other solid tumors: BRCA1 (n = 1), BRIP1 (n = 1) and CHEK2 (n = 6), that are breast cancer –predisposing genes, RET (n = 1), which predisposes to multiple endocrine neoplasia, and SDHB (n = 1) and SDHC (n = 1) that are known to predispose familial paraganglioma- pheocromocytoma (Table 2, Fig. 1a). This evidence concerns the gene BRIP1 and multiple endocrine neoplasia.