Meng et al.14 developed a prognostic model for CESC based on DSG2, ITM2A, CENPM, RIBC2, and MEIS2. Liu et al.15 developed a multi-mRNA prognostic model composed of ITGA5, HHEX, and S1PR4. Similarly, we also developed a CESC-associated prognostic model based on OPN3, DAAM2, HENMT1, and CAVIN3, and the prognostic ability of this model was indicated by AUC of 0.726 in ROC analysis. This evidence concerns the gene OPN3 and cervical squamous cell carcinoma.