Several related observations support this idea: mutations of microfibril co-regulating families of fibrillin, LTBP, ADAMTS and ADAMTSL affect the microfibril microenvironment and can yield overlapping phenotypes31–33; different fibrillin-1 and LTBP2 mutations may cause an identical clinical phenotype35 and inappropriate TGFβ signaling17,18; separate mutations of fibrillin-122, ADAMTS1031,32 and LTBP238,39 are associated with POAG; and LTBP2 mutation is associated with POAG and pseudoexfoliation glaucoma38,39,91–94 that both show aqueous humor TGFβ anomalies. This evidence concerns the gene LTBP2 and open-angle glaucoma.