No craniofacial abnormalities were seen in: F1 zygotic heterozygous fish (which best recapitulate the SMCHD1 genotypes of BAMS patients), F2 zygotic homozygous fish or even F3 MZ homozygous smchd1-null fish. The gene discussed is SMCHD1; the disease is arhinia, choanal atresia, and microphthalmia.