Unfortunately, proposed early diagnostic methods, such as circulating microRNAs,26 N-Terminal fragment of B-Type Natriuretic Peptide (NT-pro-BNP) alone27 or in adjunction with QTc measurement28, and routine electrocardiogram monitoring as a prerequisite29 have proven to be ineffective26 or been debated.30 Therefore, alternative intervention or therapeutic strategies are mandated for AP drugs-induced cardiotoxicity. Here, NPPB is linked to alkaline phosphatase measurement.