We observed lower percentages of DCs and NKs in the patients with SLE than those in the HCs and had reported in previous.8 9 Notably, our findings revealed that CD25+ CD8 αβ T-cell percentages were lower in the patients with SLE than those in the HCs even though the percentages of CD8+ αβ Treg cells were almost identical (figure 1B). This evidence concerns the gene CD8A and systemic lupus erythematosus.