In this study, we compared the immunoprofiling of patients with SLE with the HCs and found lower percentages of peripheral blood DCs, NKs, PD-L1+ PBMCs, and MHC II+ DCs and higher of CD8+ NKTreg cells, PD-1+ T cells, MHC II+ monocytes, NKs and NKT cells were found in patients with SLE. This evidence concerns the gene CD8A and systemic lupus erythematosus.