CD8A and autoimmune disease: Characteristics of CD8+ NKT cells in SLE development are contradictory because they participate in SLE progression via producing interferon-γ.32–34 However, CD8+ NKT cells reduce antigen-bearing DCs so that T-cell response and development of autoimmune diseases are attenuated.35–37 Hence, the pathological role of CD8+ NKT cells in SLE development is unclear and needs more investigation to unveil.