In particular, miR-9 reportedly regulated ferroptosis by targeting glutamic-oxaloacetic transaminase GOT1 in melanoma.53 Besides, miR-137 could negatively regulate ferroptosis by directly targeting glutamine transporter SLC1A5 in melanoma cells.17 Supplementary to these, our results illustrated that miR-21–3p upregulation contributed to IFN-γ-potentiated ferroptosis by directly targeting TXNRD1 and promoting lipid peroxidation, thus extending the regulatory network of ferroptosis-associated miRNAs and providing novel targets to increase the efficacy of immunotherapy. This evidence concerns the gene SLC1A5 and melanoma.