More importantly, Liu et al reported that the induction of ATF3 after ADORA1 inhibition promoted the expression of PD-L1 to suppress the activity of tumor-infiltrating lymphocytes and thus increased the efficacy of anti-PD-1 immunotherapy.65 Our present results indicated that ATF3 might contribute to the enhanced effect of anti-PD-1 antibody by facilitating tumor cell ferroptosis, in addition to the effect on immune checkpoint molecules and antitumor immunity. The gene discussed is PDCD1; the disease is neoplasm.