Post-junctional nitrergic and cholinergic neuroeffector responses are mediated by intramuscular ICC or ICC-IM [32–35], and purinergic inhibitory responses mediated by another class of interstitial cell known as Platelet Derived Growth Factor Receptor-positive cells or PDGFRα+ cells [42]. The gene discussed is PDGFRA; the disease is intrahepatic cholangiocarcinoma.