ROCK1 and coronary artery disorder: Of 48 variants that passed filtering in family 154, two were considered candidates for contributing to the familial CHD: ROCK1 NM_005406.2:c.2083A>T, p.Lys695*, with a CADD score of 40, and MCTP2 NM_018349.3:c.65A>C, with a CADD score of 32.7 (Table 1).