To get more insight on the biological significance of these two proteins, we have investigated their expression pattern in tissue microarray (TMAs) including NSCLC specimens and non-cancerous lung tissues (Non-CLT) via immunohistochemistry (IHC), and discussed the internal relationship between p-4EBP1 and p-eIF4E and clinical/pathological/prognostic features in NSCLC. Here, EIF4EBP1 is linked to non-small cell lung carcinoma.