Our results showed that the phosphorylation level of eIF4E was significantly increased in lung SCC and ADC, especially ADC, and high expression of p-eIF4E was associated with poor prognosis in NSCLC patients, which is consistent with other researches founded in astrocytoma and nasopharyngeal carcinoma [25,26]. This evidence concerns the gene EIF4E and astrocytoma (excluding glioblastoma).