The current clinical pipeline includes small molecules targeting USP1 (with a phase 1 clinicial trials underway sponsored by KSQ Therapeutics, Inc in advanced solid tumors) and USP30 (with clinical trial plans announced by Mission Therapeutics for kidney disease) (KSQ Therapeutics, Inc, 2022, Identifier: NCT05240898; Mission Therapeutics, 2022). This evidence concerns the gene USP1 and kidney disorder.