ZUP1 and cancer: Similarly, USP28 is a DUB that stabilizes the c-Myc transcription factor, a potent oncogene in a wide variety of human cancers, and inhibiting USP28 is expected to reduce the levels of c-Myc, and downregulate its activities (Weisberg et al., 2017; Wrigley et al., 2017; Zhou et al., 2018).