POMC and adrenal gland hyperfunction: In contrast, the functional terms associated with genes downregulated after the ACTH-induced hypercortisolemia were (Figure 2, Supplemental File S2): cell adhesion (p = 1.29 × 10−6), chemotaxis (p = 2.17 × 10−6), immune response (p = 8.05 × 10−5), collagen fibril organization (p = 1.37 × 10−4), positive regulation of cell migration (p = 1.45 × 10−4), integrin-mediated signaling pathway (p = 2.32 × 10−4) and angiogenesis (p = 1.75 × 10−3).