CD274 and familial pancreatic carcinoma: IFN-γ has been described to inhibit the proliferation and migration of PDAC (Lange et al. 2011; Zhang et al. 2018), however, high PD-L1 expression on pancreatic cancer cells has been associated with a poor prognosis in multiple previous studies (Nomi et al. 2007; Gao et al. 2018; Hu et al. 2019; Zhao and Cao 2020).