IL-8 has been found to be produced by pancreatic cancer cells and correlate with metastatic potential and epithelial-mesenchymal transition (Chen et al. 2014; Matsuo et al. 2004), which may explain the significant difference in IL-8 serum levels between locally advanced and metastatic patients observed in this study. The gene discussed is CXCL8; the disease is familial pancreatic carcinoma.