In this study, univariate analysis revealed a significant correlation of (post-resection) IL-10 and CYFRA 21–1 with poorer outcome in patients with resected PDAC, a significant correlation of IL-10 and CA 19–9 with poorer outcome in locally advanced PDAC, as well as a significant correlation of CEA, CA 19–9, and CYFRA 21–1 with poorer outcome in metastatic disease. Here, CEACAM5 is linked to metastatic neoplasm.