Here, we found that the loss-of-function mutation of the cadherin gene resulted in constitutively differential expression of 1355 genes in the midguts of the SCD-r1 strain compared with the susceptible SCD strain, including many genes related to metabolism of xenobiotics, sphingolipid signaling pathway, ribosome biogenesis and mRNA surveillance pathway. This evidence concerns the gene CDH17 and Schnyder corneal dystrophy.