CRP and Parkinson disease: Neuroinflammation and an upregulated inflammatory response have been indicated in PD by the detection of more activated microglia [42]; increased levels of cytokines in the brain, CSF, and blood [43,44,45]; and increased levels of C-reactive protein (CRP) in serum and CSF, which is produced in response to proinflammatory cytokines and is expressed in the acute phase of inflammation [46].