The antioxidant activity of pinosylvin has been extensively studied by different investigators, not only in isolated case studies but also in association with several diseases such as rheumatoid arthritis, age-related diseases (age-related macular degeneration (AMD) and Alzheimer’s disease), and oligoasthenospermia by reducing oxidative stress via the nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway [16,17,18,19]. Here, NFE2L2 is linked to rheumatoid arthritis.