EZH2 and melanoma: Xu et al. showed that GAS5 could reverse the effect of EZH2 in melanoma cells by recruiting transcription factor E2F4, which acts as transcriptional repressor to the EZH2 promoter region, therefore affecting the EZH2 expression from the transcriptional level and eventually leads to upregulation of tumor suppressor gene CDKN1C [59].