GAS5 and neoplasm: Furthermore, via sponging miR-221 and elevating suppressor of cytokine signaling 3 (SOCS3) gene expression, overexpression of GAS5 was reported to inhibit gemcitabine resistance-mediated stem cell-like features, tumor metastasis, and epithelial-mesenchymal transition (EMT) of pancreatic cancer cells [97].