The lncRNA EPR (epithelial cell program regulator) promotes epithelial trait preservation and suppresses cancer cell proliferation via cyclin-dependent kinase inhibitor 1A (Cdkn1a) expression, which is regulated by EPR through enhancing the SMAD3-Cdkn1a promoter binding and preventing KHSRP- (KH-type splicing regulatory protein) mediated destabilization of Cdkn1a mRNA [147]. This evidence concerns the gene CDKN1A and cancer.