ZEB2 and colon adenocarcinoma: Interestingly, the transcription of ZEB2 is also regulated by its natural antisense transcript ZEB2 NAT, which overlaps the splicing site at 5′UTR of ZEB2 as a potential internal ribosome entry site (IRES) sequence to promote ZEB2 translation, accounting for the EMT of colon adenocarcinomas and urinary bladder cancer cells [128,129].