TGFB1 and hepatocellular carcinoma: In hepatocellular carcinoma cells, TGF-β1 induced the enrichment of lincRNA-ROR (linc-ROR) in extracellular vesicles, promoting the formation of spheroid CD133+ stem-like cells against sorafenib-, doxorubicin-, and camptothecin-induced cancer cell death [130].