While rs174537 actually lies in the intron of the myelin regulatory factor gene with no reported function related to MetS features, the associations reported in this and previous studies (98 significant rs174537 associations are listed in the NHGRI-EBI catalog of human genome-wide association studies [75]) most likely reflect the near-complete linkage disequilibrium with other FADS1 variants. The gene discussed is FADS1; the disease is metabolic syndrome.