FADS2 and obesity due to melanocortin 4 receptor deficiency: Some studies have found associations between FADS1/FADS2 variants (rs174546, rs174550, rs174537, rs174575, and rs174570) and insulin sensitivity, the serum glucose level, and risk of T2DM [43,44,45], while others have linked FADS1/FADS2 variants (rs1535, rs174547, rs174546, rs174537, rs174549, and rs9957425) to increased blood pressure (arterial hypertension, respectively) and obesity [46,47,48,49,50].