The main result of our study was the statistically significant genotype associations of FADS1 SNPs (rs174537, rs174545, and rs174546; all p < 0.01), FADS2 SNPs (rs174570 and 174602, both p < 0.05), and two inferred haplotypes (GGGCC (p < 0.01) and TCACT (p < 0.05)) with the splitting of MetS into two phenotypes (MetS1 and MetS2). The gene discussed is FADS1; the disease is metabolic syndrome.