SNPs of FADS1–FADS2 genes have been strongly associated with various metabolic phenotypes/traits, including obesity, T2DM, dyslipidemia, and complex conditions, such as coronary artery disease (CAD), ischemic stroke, and NAFLD [18,26,27,28]. The gene discussed is FADS1; the disease is obesity due to melanocortin 4 receptor deficiency.