FADS2 and obesity due to melanocortin 4 receptor deficiency: SNPs of FADS2 (rs174593, rs174616, and rs175576) have been documented to play a role in the interaction of polyphenols with PUFA levels and parameters of obesity [72], while lower levels of TC, LDL-C, and HDL-C have been associated with the minor allele of FADS1 rs174547 [73].