ALF is very likely to occur when hepatic injury (ALT/AST > 3 × upper limit of normal (ULN)), jaundice (TB > 2 × ULN), or liver dysfunction (INR > 1.5 × ULN) and in the absence of obstructive cholestasis (ALP < 2 × ULN) and excluded from other disease-induced liver damage [25]. This evidence concerns the gene GPT and Jaundice.