Galactosylceramidase (GALC) and ceramide galactosyltransferase (UGT8) are involved in the metabolism of ceramide to galactosylceramide; GALC expression was significantly higher in ALS compared to control (Figure 6d; p = 0.0009), but there was no difference in UGT8 expression (Figure 6e; p = 0.16). The gene discussed is GALC; the disease is amyotrophic lateral sclerosis.