Several studies have described the use of molecular markers characterizing the cellular pathways involved in tumor growth and spread (p53, RB, PI3K/Akt/mTOR, and Ras/MAPK) [16,17], as well as the tumor immune microenvironment, including tumor lymphoid infiltration (TILs) to determine the prognosis of breast cancer [18,19,20]. This evidence concerns the gene RB1 and neoplasm.