In addition, the levels of serum urea nitrogen (BUN), creatinine, alanine aminotransferase, (ALT) and aspartate aminotransferase (AST) were assayed, and the weight of kidney and liver was measured to understand the protective effects of submerged G. lucidum culture against hyperuricemia-associated renal and hepatic damage. This evidence concerns the gene GPT and hyperuricemia.