Magomi et al. suggest that ISL is one of the most important active components in TJ-43, acting as an antagonist to both CRF receptor 1 (CRFR1) and serotonin 2C receptor (5-HT2CR) in order to reduce ghrelin secretion, which further improves stress-induced anorexia [94,95,99]. Here, GHRL is linked to Anorexia.