AR and metabolic dysfunction-associated steatotic liver disease: The androgen receptor agonist oxandrolone, also predicted to revert 7 of the 12 signatures, promoted hepatic ketogenesis in an observational trial of adult males [48] consistent with enhanced fatty acid partitioning from intrahepatic triglycerides towards mitochondrial beta oxidation and 4-hydroxybutyrate formation, as proposed for the reversal of NAFLD resulting from a short-term ketogenic diet [49,50].