INS and metabolic syndrome: A large and diverse set of biomarkers and image-based analyses measured over time under different media that reflect normal fasting and early and late metabolic syndrome conditions indicated that the human LAMPS also recapitulates critical aspects of NAFLD progression (e.g., simple steatosis, lipotoxicity, oxidative stress, insulin resistance, lobular inflammation, stellate cell activation, and fibrosis) [16,41].