Targeting NAFLD-associated hepatic proteins that have critical roles both in xenobiotic and endobiotic metabolism may be an emerging theme (see Discussion and [52]) that can be extended to nuclear receptor transcription factors as the diverse drugs tetracycline, SN-38, and the endogenous steroid, pregnanolone, have been shown to interact with PXR [53,54]. The gene discussed is NR1I2; the disease is metabolic dysfunction-associated steatotic liver disease.