LIPA and Familial prostate cancer: Recently, Raftopulos et al. reported that the inhibition of KIAA1363 by JW480 reduced in vitro cholesterol ester hydrolase activity in human prostate cancer–derived C4-2B cells by 75% and increased cellular cholesterol ester levels of lipoprotein-loaded cells, thereby reducing lipoprotein-mediated cell proliferation, suggesting that cholesterol availability and cholesteryl ester turnover may affect prostate cancer cell proliferation and aggressiveness [65].