Lipidomics + Metabolomics:IPI-9119, a selective inhibitor of FASN altered the PCa metabolome by inhibiting fatty acid oxidation via accumulating malonyl-coA carnitine.Malonyl-coA carnitine accumulation → inhibited carnitine palmitoyltransferase 1 → FAO suppression.FA synthesis suppression → inhibited AR and AR-V7 expression.IPI-9119 → induced ER stress, inhibited AR/AR-V7 translation. The gene discussed is FASN; the disease is posterior cortical atrophy.