Transcriptomic profiling of MCs isolated from prostate tumor region → downregulated SAMD14.Proteomic profiling of HMC-1 → overexpression of SAMD14 → modified proteins associated w/ immune regulation and ECM processes.Add HMC-1-SAMD14+ medium to culture of (CAF + prostate epithelium) → reduced deposition and alignment of ECM generated by CAF; suppressed tumorigenic morphology of prostate epithelium. Here, SAMD14 is linked to prostate neoplasm.