ARB1 contributes to PCa metabolic shift via regulation of hypoxia-inducible factor 1A (HIF1A) transcription through regulation of succinate dehydrogenase and fumarate hydratase in normoxic conditions.ARB1 was directly linked in PCa as a promoter by altering metabolic pathways.Survival of PCa cells in harsh conditions due to ARB1. This evidence concerns the gene ARRB1 and posterior cortical atrophy.