Another conflicting result among most of these validation studies is that the knockdown of glycine-N-methyltransferase (GNMT), the glycine-producing sarcosine enzyme, inhibits PCa cell proliferation to further abolish malignancy via G1 cell cycle arrest and apoptosis in certain allelic frequencies and ethnicities, with only a few studies finding opposite conclusions [125,126,127,128,129,130,131]. The gene discussed is GNMT; the disease is posterior cortical atrophy.