Cysteine, methionine, and nicotinamide adenine dinucleotide metabolisms and hexosamine biosynthesis were aberrantly altered in PCT vs. ANT.Sphingosine was able to distinguish PCa from BHP cells for patients w/ low PSA levels.The loss of sphingosine-1-phosphate receptor 2 signaling → loss of TSG (oncogenic pathway). This evidence concerns the gene S1PR2 and posterior cortical atrophy.