NFKB1 and Fever: WB results show that (in the hypothalamus) P-NF-κB P65 and IKB-α levels increased after successful modeling of a fever model, while the treatment with EA led to a significant decrease in P-NF-κB P65 levels, suggesting that the inducers are recognized and bound to the pattern recognition receptors on yeast cells, which activate IKB-α and are further ubiquitinated.