APOE and Alzheimer disease: Accordingly, the TT genotype at MTHFD1 (rs1076991) (OR: 14.00, 95% CI: 2.079–94.24), GG at MTHFD1 (rs2236225) (OR: 2.06, 95% CI: 0.455–9.304), CC at SOD2 (rs2758331) (OR: 10.00, 95% CI: 1.594–62.73), and E3/E4 at APOE (OR: 16.50, 95% CI: 2.818–96.61) showed statistically significant differences among the controls and AD patients (Supplementary Table S2).