In an experimental autoimmune encephalomyelitis (EAE) murine model of multiple sclerosis (MS), DFMO and AMXT abrogated pathogenesis, which the authors attributed to the reduction in CD4+ T cell infiltration and in IL-17+ CD4+ T cells; however, the disease state induces hyper-recruitment of a complex array of immune cells [18,19]. The gene discussed is CD4; the disease is experimental autoimmune encephalomyelitis.