SLC25A4 and Sensorineural hearing impairment: Human diseases have been also associated with defects in ANT1, encoded by SLC25A4. Monoallelic pathogenic variants in SLC25A4 cause adult-onset progressive external ophthalmoplegia that could be associated with exercise intolerance, muscle weakness, sensorineural hearing impairment, psychiatric illnesses, and multiple mtDNA deletions [94].