An increased number of CD4, CD8 T cells, CD19, and early mature and mature NK cells was found in both groups mildly treated with RtH-GD3P4 or HaH-GD3P4 vaccines, while the percentage of activated CD8 T lymphocytes as well as the macrophages remained unchanged compared to untreated tumor-bearing mice (Figure 3B, left panel). This evidence concerns the gene CD4 and neoplasm.