The results of the dual-luciferase reporter gene assay demonstrated that oncoVV-AVL significantly reduced the expression of ISRE (Figure 4b), suggesting that although oncoVV-AVL enhanced the production of IFN, the infection with oncoVV-AVL also downregulated the expression of ISGs through downregulating the level of ISRE in Huh7 cells. Here, IFNA1 is linked to infection.