BC cells are able to secrete pro-angiogenic factors, such as fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), interleukins (ILs), transforming growth factor beta (TGF-β), platelet-derived growth factor (PDGF), that control the angiogenesis and metastasis since they can trigger neovascularization [131]. The gene discussed is VEGFA; the disease is breast cancer.