Terasaki et al. studied Fx-related changes in the transcriptome of tumor-associated proteins in the colon mucosal tissues of AOM/DSS mice treated with or without Fx and showed that Fx produced chemoprophylaxis in AOM/DSS mice by decreasing chemokine (C-C motif) receptor 1 (CCR1) expression along with 11 cancer-related signals [126]. The gene discussed is CCR1; the disease is infectious otitis media.