AKT1 and colorectal carcinoma: Actinomycin V induced apoptosis in CRC cells via mitochondrial and PI3K/AKT pathways, with this being characterized by mitochondrial dysfunction manifested by the loss of mitochondrial membrane potential (MMP) and cytochrome C release, which then activated cleaved caspase-9, cleaved caspase-3, and cleaved poly ADP-ribose polymerase (PARP); however, this apoptotic trend could be reversed by the caspase inhibitor Z-VAD-FMK [19].