Stepping away from the established concept of establishing parallels between manifestations of a syndrome and the associated deleted/overrepresented genes in linear pathogenic linkage—for example, DiGeorge syndrome and TBX1 deletion included within the 22q11.2 deletion explaining the cardiac involvement—the syndrome could effectively be classified as regulopathy, as for each example, crucial DNA regulation genes are involved and have consequences that have rippling repercussions on more than the affected regions. The gene discussed is TBX1; the disease is 22q11.2 deletion syndrome.