Mutations in sarcomeric genes including ACTC1 (cardiac actin alpha), TNNT2, TNNI3, TNNC1 (troponin T2, I3 and C1), MHY7 (β- myosin heavy chain), TPM1 (tropomyosin-1), PLN (phospholamban), MYBPC3 (myosin binding protein C) and SCN5A (Sodium channel protein type 5 subunit alpha) are associated with DCM (Table 2). The gene discussed is TNNC1; the disease is familial dilated cardiomyopathy.