EDN1 and familial dilated cardiomyopathy: The role of the endothelin 1 gene (EDN1) was investigated by Matsa et al. in the manifestation of DCM in 115 DCM patients from a hospital in Hyderabad, using PCR-based followed by single-stranded confirmation polymorphism analysis along with the commercial screening insertion variation (+138 A) in a heterozygotic state leading to a four-fold increased risk of DCM [141].