Alarmins S100A8 and S100A9 are of particular importance in MDS, because—via autocrine and paracrine actions—they drive TLR4 activation, NLR family pyrin domain-containing protein 3 (NLRP3) inflammasome assembly, and microenvironmental immunosuppression [6]. The gene discussed is S100A8; the disease is myelodysplastic syndrome.