Pyroptosis—a form of programmed cell death—being driven by NLRP3 inflammasome activation, is responsible for cellular death in MDS, being a point of convergence for cell-intrinsic, (e.g., gene mutations) and cell-extrinsic, (e.g., DAMPs) pathogenesis mechanisms [57]. The gene discussed is NLRP3; the disease is myelodysplastic syndrome.