Briefly, the reduction of the 5′-adenosine monophosphate-activated protein kinase, mediated by insulin resistance and adiponectin depletion together with the reduced activity of peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1a) and the myocyte enhancer factor 2 are the main contributors of the switch towards the fast glycolytic types of fibers. Here, ADIPOQ is linked to Insulin resistance.