CD4 and neoplasm: Previous studies have found that T cells and macrophages represented the dominant populations in most KIRC cases [73,74], consistent with our findings, which indicates that GOT2 expression was more likely to affect the tumor infiltration of subtypes of T cells, especially CD8+ T cells and follicular helper CD4+ T (Tfh) cells, and M1 and M2 macrophages compared to normal renal tissue.