GOT2, situated on chromosome 16q21, is a crucial enzyme for cancer cell metabolism, (i) mediating the reversible interconversion of oxaloacetate and glutamate into aspartate and α-ketoglutarate, providing energy for tumor cells (Krebs cycle) [29]; (ii) being a key transfer enzyme in the malate-aspartate NADH shuttle activity and oxidative protection [30], maintaining glycolysis, and (iii) participating in the amino acid metabolism of tumor cells [31]. Here, GOT2 is linked to cancer.