However, a comprehensive characterization of immune cells from KIRC patients using scRNA-seq along with T-cell-receptor (TCR) sequencing revealed that CD8+ T-cells exhibited four distinct groups that may represent transcriptional states upon tumor infiltration with distinct prognostic significance: two of them were associated with a PD-1+TIM-3+ exhausted subcluster, one with a proliferative subcluster, and a fourth with the higher levels of cytokine signaling [73]. This evidence concerns the gene CD8A and neoplasm.