TNF and rheumatoid arthritis: An Enrichr analysis using the drug perturbations from GEO down signatures indicated drugs with similar signatures and included several conditions relating to reduced inflammation and RA, such as methotrexate, curcumin, resveratrol, celecoxib (which include JAK-STAT3 inhibition among its mechanisms [39,40,41,42]), and other anti-inflammatory drugs utilizing diverse mechanisms such as anti-IFNβ1, the TNF inhibitor etanercept, and the BRAF inhibitor vemurafenib (Figure 8C).