An Enrichr analysis using the drug perturbations from GEO down signatures indicated drugs with similar signatures and included several conditions relating to reduced inflammation and RA, such as methotrexate, curcumin, resveratrol, celecoxib, suggesting inhibition of JAK-STAT3 may be a particular way in which pathways modulated by these drugs (or P) can interact with IL-27. This evidence concerns the gene IL27 and rheumatoid arthritis.