We identified male sex, cirrhosis, AFP ≥ 100 μg/L, AST ≥ 70 u/dL, total bilirubin (>2.0 mg/dL), INR > 1.7, SII > 610 × 109 cells/L, advanced tumor stage TNM, and MELD score as risk factors for poor outcomes. The gene discussed is AFP; the disease is neoplasm.