Nivolumab demonstrated a significant increase in OS compared to the standard therapy (HR 0.70, p = 0.01) irrespective of PD-L1 tumor expression or HPV status, with estimated 24-month OS nearly tripling from 6.0% to 16.9% for patients on nivolumab; however, the survival benefit was greater with nivolumab in the PD-L1+ subgroup, 57.3% of all PD-L1 evaluable patients, (HR 0.55) compared to PD-L1− population (HR 0.89) [26]. Here, CD274 is linked to neoplasm.